Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC032
Test administered by neuromedic@manusdevices.net
Test date and time 2022-07-28 08:55
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 2x1/2

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.67 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.67 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 12, 'TN': 11, 'TP': 30, 'FP': 19}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 31, 'TN': 26, 'TP': 11, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 5, 'TN': 2, 'TP': 37, 'FP': 28}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 5.936
timePerCircleCoV 0.0658097
timePerCircleSlope -0.0191946
meanError 4.21208
tremorFreq 7.8125
tremorRelPower 29.5117
tremorGyroAmpMean 0.0165236
tremorGyroAmpSlope -0.00258547
tremorGyroAmpCoV 0.33657
tremorCoordAmpMean 0.0353788
tremorCoordAmpSlope 0.00353486
tremorCoordAmpCoV 0.223031
tremorAccAmpMean 0.0425379
tremorAccAmpSlope 0.000380535
tremorAccAmpCoV 0.0898469
tremorPcRelVar 0.61222
tremorPcX 0.623056
tremorPcY 0.782178

Circle Segment 1

Duration 6.32 s, Accuracy Estimate 5.582 (lower is better)

Circle Segment 2

Duration 6.36 s, Accuracy Estimate 4.076 (lower is better)

Circle Segment 3

Duration 6.2 s, Accuracy Estimate 3.779 (lower is better)

Circle Segment 4

Duration 6.32 s, Accuracy Estimate 3.74 (lower is better)

Circle Segment 5

Duration 5.92 s, Accuracy Estimate 3.578 (lower is better)

Circle Segment 6

Duration 5.64 s, Accuracy Estimate 4.053 (lower is better)

Circle Segment 7

Duration 6.16 s, Accuracy Estimate 3.972 (lower is better)

Circle Segment 8

Duration 5.64 s, Accuracy Estimate 3.972 (lower is better)

Circle Segment 9

Duration 5.52 s, Accuracy Estimate 4.705 (lower is better)

Circle Segment 10

Duration 5.28 s, Accuracy Estimate 4.663 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 21.78
timePerSpiralCoV 0.0816627
timePerSpiralSlope -0.00479728
meanError 2.0524
tremorFreq 6.64062
tremorRelPower 22.9056
tremorGyroAmpMean 0.015209
tremorGyroAmpSlope 0.00114147
tremorGyroAmpCoV 0.337755
tremorCoordAmpMean 0.0328347
tremorCoordAmpSlope 0.000978514
tremorCoordAmpCoV 0.296321
tremorAccAmpMean 0.0213122
tremorAccAmpSlope 0.000244439
tremorAccAmpCoV 0.460433
tremorPcRelVar 0.636794
tremorPcX -0.721404
tremorPcY -0.692515

Spiral Segment 1

Duration 20.44 s, Accuracy Estimate 3.912 (lower is better)

Spiral Segment 2

Duration 21.88 s, Accuracy Estimate 2.054 (lower is better)

Spiral Segment 3

Duration 22.2 s, Accuracy Estimate 1.747 (lower is better)

Spiral Segment 4

Duration 21.44 s, Accuracy Estimate 1.902 (lower is better)

Spiral Segment 5

Duration 22.24 s, Accuracy Estimate 1.517 (lower is better)

Spiral Segment 6

Duration 25.92 s, Accuracy Estimate 1.638 (lower is better)

Spiral Segment 7

Duration 22.88 s, Accuracy Estimate 1.88 (lower is better)

Spiral Segment 8

Duration 21.0 s, Accuracy Estimate 1.984 (lower is better)

Spiral Segment 9

Duration 20.16 s, Accuracy Estimate 2.049 (lower is better)

Spiral Segment 10

Duration 19.64 s, Accuracy Estimate 1.841 (lower is better)

Elel

eDurationMean 0.64075
eDurationStd 0.100093
eDurationStdnorm 0.156213
eDurationMedian 0.6175
eDurationQuartdelta 0.1575
eDurationQuartdeltanorm 0.255061
eDurationKurt 3.15005
eDurationTrenddiff -0.095
eDurationTrendratio 0.862319
eWidthMean 4.89645
eWidthStd 1.08098
eWidthStdnorm 0.220768
eWidthMedian 4.797
eWidthQuartdelta 1.521
eWidthQuartdeltanorm 0.317073
eWidthKurt 3.47472
eWidthTrenddiff -0.117
eWidthTrendratio 0.97619
eHeightMean 10.2229
eHeightStd 1.54667
eHeightStdnorm 0.151295
eHeightMedian 10.1205
eHeightQuartdelta 1.9305
eHeightQuartdeltanorm 0.190751
eHeightKurt 3.58821
eHeightTrenddiff -1.638
eHeightTrendratio 0.847826
eAspectMean 0.48734
eAspectStd 0.125917
eAspectStdnorm 0.258375
eAspectMedian 0.471196
eAspectQuartdelta 0.158481
eAspectQuartdeltanorm 0.336338
eAspectKurt 4.45551
eAspectTrenddiff 0.0962342
eAspectTrendratio 1.23299
eSlantMean -0.0826293
eSlantStd 0.16596
eSlantStdnorm -2.00849
eSlantMedian -0.0643093
eSlantQuartdelta 0.177034
eSlantQuartdeltanorm -2.75285
eSlantKurt 3.44692
eSlantTrenddiff 2.36323e-05
eRtopMean 0.664841
eRtopStd 0.138469
eRtopStdnorm 0.208274
eRtopMedian 0.66369
eRtopQuartdelta 0.196047
eRtopQuartdeltanorm 0.295389
eRtopKurt 2.73199
eRtopTrenddiff 0.0634073
eRbotMean 0.884152
eRbotStd 0.270506
eRbotStdnorm 0.30595
eRbotMedian 0.824324
eRbotQuartdelta 0.359028
eRbotQuartdeltanorm 0.435542
eRbotKurt 2.48589
eRbotTrenddiff 0.0289939
eRrightMean 0.836583
eRrightStd 0.0802878
eRrightStdnorm 0.0959711
eRrightMedian 0.839352
eRrightQuartdelta 0.117382
eRrightQuartdeltanorm 0.139848
eRrightKurt 2.41711
eRrightTrenddiff 0.0222052
eRleftMean 0.475541
eRleftStd 0.119803
eRleftStdnorm 0.251931
eRleftMedian 0.457738
eRleftQuartdelta 0.122466
eRleftQuartdeltanorm 0.267545
eRleftKurt 3.4868
eRleftTrenddiff -0.0202929
lDurationMean 0.817895
lDurationStd 0.133673
lDurationStdnorm 0.163435
lDurationMedian 0.82
lDurationQuartdelta 0.155
lDurationQuartdeltanorm 0.189024
lDurationKurt 4.9432
lDurationTrenddiff -0.115
lDurationTrendratio 0.865497
lWidthMean 5.81613
lWidthStd 1.34062
lWidthStdnorm 0.2305
lWidthMedian 5.6745
lWidthQuartdelta 1.872
lWidthQuartdeltanorm 0.329897
lWidthKurt 2.28284
lWidthTrenddiff -0.117
lWidthTrendratio 0.979592
lHeightMean 21.3894
lHeightStd 4.28945
lHeightStdnorm 0.200541
lHeightMedian 20.5335
lHeightQuartdelta 5.148
lHeightQuartdeltanorm 0.250712
lHeightKurt 3.37067
lHeightTrenddiff -4.914
lHeightTrendratio 0.793103
lAspectMean 0.27933
lAspectStd 0.0726605
lAspectStdnorm 0.260125
lAspectMedian 0.271584
lAspectQuartdelta 0.0899455
lAspectQuartdeltanorm 0.331189
lAspectKurt 2.5104
lAspectTrenddiff 0.06816
lAspectTrendratio 1.27673
lSlantMean -0.0649557
lSlantStd 0.0764822
lSlantStdnorm -1.17745
lSlantMedian -0.0526486
lSlantQuartdelta 0.0742169
lSlantQuartdeltanorm -1.40967
lSlantKurt 3.30623
lSlantTrenddiff 0.0190726
lRtopMean 0.749824
lRtopStd 0.101936
lRtopStdnorm 0.135947
lRtopMedian 0.754301
lRtopQuartdelta 0.149184
lRtopQuartdeltanorm 0.197778
lRtopKurt 2.70304
lRtopTrenddiff 0.0358423
lRbotMean 1.04827
lRbotStd 0.368374
lRbotStdnorm 0.351411
lRbotMedian 0.973001
lRbotQuartdelta 0.290996
lRbotQuartdeltanorm 0.29907
lRbotKurt 8.06647
lRbotTrenddiff -0.0287805
lRrightMean 0.87364
lRrightStd 0.0613555
lRrightStdnorm 0.0702297
lRrightMedian 0.875031
lRrightQuartdelta 0.0851389
lRrightQuartdeltanorm 0.0972982
lRrightKurt 3.094
lRrightTrenddiff 0.0568182
lRleftMean 0.385941
lRleftStd 0.0991175
lRleftStdnorm 0.25682
lRleftMedian 0.384703
lRleftQuartdelta 0.123247
lRleftQuartdeltanorm 0.320368
lRleftKurt 3.08424
lRleftTrenddiff 0.0222481

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.857143
sumTouchScores 6
meanMovementTime 0.56
numTouches 7
undershootPercentage 14.2857
overshootPercentage 0

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.805951
sumTouchScores 13.7012
meanMovementTime 1.13094
numTouches 17
undershootPercentage 0
overshootPercentage 17.6471

ZigZag

numZigzags 5
timePerZigzagMean 16.488
timePerZigzagCoV 0.0492545
timePerZigzagSlope -0.0288695
meanError 2.25872
tremorFreq 6.44531
tremorRelPower 20.8065
tremorGyroAmpMean 0.023503
tremorGyroAmpSlope 0.0041183
tremorGyroAmpCoV 0.289291
tremorCoordAmpMean 0.0526092
tremorCoordAmpSlope 0.00277583
tremorCoordAmpCoV 0.292157
tremorAccAmpMean 0.0402496
tremorAccAmpSlope 0.0020762
tremorAccAmpCoV 0.303364
tremorPcRelVar 0.626339
tremorPcX 0.465237
tremorPcY -0.885186

ZigZag Segment 1

Duration 17.6 s, Accuracy Estimate 2.157 (lower is better)

ZigZag Segment 2

Duration 16.8 s, Accuracy Estimate 2.064 (lower is better)

ZigZag Segment 3

Duration 16.64 s, Accuracy Estimate 2.146 (lower is better)

ZigZag Segment 4

Duration 15.56 s, Accuracy Estimate 2.394 (lower is better)

ZigZag Segment 5

Duration 15.84 s, Accuracy Estimate 2.532 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 15.096
timePerZigzagCoV 0.00610009
timePerZigzagSlope -0.00105988
zigzagHeightMean 71.1768
zigzagHeightCoV 0.0310667
zigzagHeightSlope 0.00284836
meanError 0.033093
tremorFreq 6.93359
tremorRelPower 24.8041
tremorGyroAmpMean 0.0289061
tremorGyroAmpSlope -0.00047904
tremorGyroAmpCoV 0.285228
tremorCoordAmpMean 0.0670053
tremorCoordAmpSlope 0.00106422
tremorCoordAmpCoV 0.190431
tremorAccAmpMean 0.0482886
tremorAccAmpSlope -0.000713963
tremorAccAmpCoV 0.222999
tremorPcRelVar 0.709131
tremorPcX 0.28643
tremorPcY -0.958101

ZigZag Offset Segment 1

Duration 15.08 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 2

Duration 15.24 s, Accuracy Estimate 0.023 (lower is better)

ZigZag Offset Segment 3

Duration 15.04 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 4

Duration 15.0 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 5

Duration 15.12 s, Accuracy Estimate 0.038 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.84}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.67}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.4089116410360467}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9193736753039234}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7287825057071955}